Reaktion #170501

Reaktionsgleichung

6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

rac-2-amino-1-propanol

→

title compound

Ausbeute 89.0%

N-(2-Hydroxy-1-methyl-ethyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide

Ausbeute 89.0%

Reaktionsbedingungen

Vorschrift

As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (150 mg, 0.5 mmol) was converted, using rac-2-amino-1-propanol instead of methylamine, to the title compound (158 mg, 89%) which was obtained as a white solid. MS: m/e=368.2 [M+H]+.

Quelle