Reaktion #1704892

ord-93a82144abad4c83a72081c9a3763376

Reaktionsgleichung

Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N(C)CCO)cc1
N-(2-hydroxy-ethyl)-N-methyl-4-[3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-1-o-tolyl-propyl]-benzamide
Cl.NO
hydroxylamine hydrochloride
O=C([O-])O.[Na+]
NaHCO3
→
Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N(C)CCO)cc1
title compound
Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N(C)CCO)cc1
N-(2-Hydroxy-ethyl)-4-[3-[(E)-hydroxyimino]-3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-1-o-tolyl-propyl]-N-methyl-benzamide

Edukte

Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N(C)CCO)cc1
N-(2-hydroxy-ethyl)-N-methyl-4-[3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-1-o-tolyl-propyl]-benzamide
Cl.NO
hydroxylamine hydrochloride
O=C([O-])O.[Na+]
NaHCO3

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 151, step 3, N-(2-hydroxy-ethyl)-N-methyl-4-[3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-1-o-tolyl-propyl]-benzamide was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI+): m/z=448.2 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08765730B2uspto-grants-2014_07