Reaktion #1704817

ord-305a4a3b57e5403c8c706dbfbefc5b46

Reaktionsgleichung

Cc1ccccc1C(CC(=O)c1ccc(=O)[nH]c1)c1ccc(Br)cc1
5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one
CI
iodomethane
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1
title compound
Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1
5-[3-(4-Bromo-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Edukte

Cc1ccccc1C(CC(=O)c1ccc(=O)[nH]c1)c1ccc(Br)cc1
5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one
CI
iodomethane
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 161, step 1, 5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a colorless solid, MS (ESI+): m/z=410.2 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08765730B2uspto-grants-2014_07