Reaktion #170442

Reaktionsgleichung

4-fluoroacetophenone

ethyl trifluoroacetate

sodium methoxide

→

title compound

Ausbeute 97.0%

4,4,4-Trifluoro-1-(4-fluoro-phenyl)-butane-1,3-dione

Ausbeute 97.0%

Lösungsmittel

HCl

tertbutylmethylether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   TrocknenThe combined organic extracts were then dried over sodium sulfate
3. 3
   Sonstigeevaporated

Vorschrift

To a solution of ethyl trifluoroacetate (23.9 mL, 199 mmol) in tertbutylmethylether (230 mL) containing sodium methoxide (5.4 M, 39.6 mL, 214 mmol) was added 4-fluoroacetophenone (25 g, 181 mmol) and the resulting mixture stirred at room temperature for 3 h and then poured into ice-water. The mixture was then diluted with HCl (2 N, 200 mL) and then extracted with ethyl acetate. The combined organic extracts were then dried over sodium sulfate and evaporated to afford the title compound (40.9 g, 97%) which was obtained as an orange oil. MS: m/e=232.9 [M−H]−.

Quelle