Reaktion #170396

Reaktionsgleichung

3-chlorobenzaldehyde

hydroxylamine hydrochloride

sodium acetate

→

title compound

Ausbeute 98.0%

(Z)-3-Chloro-benzaldehyde oxime

Ausbeute 98.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 3 h
3. 3
   Sonstigeprecipitated
4. 4
   workup.ADDITIONthe resulting mixture was then diluted with water
5. 5
   FiltrationThe white precipitate was then filtered off
6. 6
   Waschenwashed with water
7. 7
   Sonstigedried under high vacuum

Vorschrift

To a suspension of 3-chlorobenzaldehyde (50 g, 355 mmol) and hydroxylamine hydrochloride (38 g, 543 mmol) in ethanol (200 mL) containing sodium acetate (46 g, 558 mmol) was heated under reflux for 3 h. After 30 min stirring at room temperature a white solid precipitated and the resulting mixture was then diluted with water and acidified with HCl (4 N). The white precipitate was then filtered off, washed with water and dried under high vacuum to afford the title compound (54 g, 98%) which was obtained as a white solid. Mp: 64-66° C.

Quelle