Reaktion #170283

Reaktionsgleichung

HCl

1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one

→

title compound

Ausbeute 71.3%

3-(3-chloro-2-hydroxypropoxy)-1-methoxy-9H-xanthen-9-one

Ausbeute 71.3%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction solvent was removed under reduced pressure
2. 2
   workup.ADDITIONEther was added to the residue
3. 3
   Sonstigefollowed by sonication
4. 4
   Sonstigethe solvent was removed

Vorschrift

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (25 mg, 0.08 mmol) prepared in Step 4 of Example 9, followed by stirring at room temperature for 30 minutes, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (20 mg, 71.3%) as a reddish brown solid.

Quelle