Reaktion #170255

Reaktionsgleichung

Potassium hydroxide

thiophene-2-thiol

Potassium hydroxide

thiophene-2-thiol

1-benzhydrylazetidin-3-yl methanesulfonate

→

title product

1-Benzhydryl-3-(thiophen-2-ylthio)-azetidine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture was stirred for a second time under microwave irradiations (100 W) at 80° C. for 30 minutes
2. 2
   EinengenAfter concentration to dryness
3. 3
   Sonstigethe residue was purified by chromatography on silica gel

Vorschrift

Potassium hydroxide (141 mg, 2.52 mmol) and thiophene-2-thiol (292 mg, 238 μL) were added to a solution of 1-benzhydrylazetidin-3-yl methanesulfonate (400 mg, 1.26 mmol) solubilized in THF (7 mL). The reaction mixture was stirred a first time under microwave irradiations (100 W) at 80° C. for 30 minutes. Potassium hydroxide (141 mg, 2.52 mmol) and thiophene-2-thiol (292 mg, 238 μL) were added and the reaction mixture was stirred for a second time under microwave irradiations (100 W) at 80° C. for 30 minutes. After concentration to dryness, the residue was purified by chromatography on silica gel using petroleum ether/ethyl acetate (1:0 to 9:1) as eluent. The title product was obtained as a yellow solid (160 mg, 37%).

Quelle