Reaktion #170251

Reaktionsgleichung

ethyl acetate

Potassium iodide

1-benzhydrylazetidin-3-yl methanesulfonate

→

title compound

1-Benzhydryl-3-iodoazetidine

Lösungsmittel

water

water

1,2-dimethoxyethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was then heated up
2. 2
   Temperaturto reflux
3. 3
   SonstigeThe aqueous phase was separated
4. 4
   Extraktionextracted with ethyl acetate (2×70 mL)
5. 5
   WaschenThe combined organic phases were washed with a saturated solution of sodium chloride (40 mL)
6. 6
   Trocknendried over sodium sulfate
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated to dryness

Vorschrift

Potassium iodide (530 mg, 3.14 mmol) was added to a solution of 1-benzhydrylazetidin-3-yl methanesulfonate (500 mg, 1.57 mmol) in a mixture of water (2.5 mL) and 1,2-dimethoxyethane (2.5 mL) at room temperature. The reaction mixture was then heated up to reflux and stirred for 3 hours. After cooling down to room temperature, the reaction mixture was diluted by addition of water (50 mL) and ethyl acetate (50 mL). The aqueous phase was separated and extracted with ethyl acetate (2×70 mL). The combined organic phases were washed with a saturated solution of sodium chloride (40 mL), dried over sodium sulfate, filtered and concentrated to dryness. The title compound was obtained as a yellow solid (550 mg, 100%).

Quelle