Reaktion #170240

Reaktionsgleichung

Triethylamine

1-benzhydrylazetidin-3-ol

→

title product

1-Benzhydrylazetidin-3-one

Lösungsmittel

DMSO

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat room temperature for 4 hours
2. 2
   Sonstigesubsequently quenched
3. 3
   workup.ADDITIONby pouring
4. 4
   Sonstigeonto crushed ice (˜200 g)
5. 5
   Extraktionextracted with ethyl acetate (3×200 mL)
6. 6
   WaschenThe combined organic layers were washed with water (400 mL) and brine (400 mL)
7. 7
   Trocknendried over sodium sulfate
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated under reduced pressure
10. 10
    SonstigeThe residue was purified by column chromatography on silica gel

Vorschrift

Triethylamine (29.1 mL, 209 mmol) and a solution of sulphur trioxide pyridine complex (21.3 g, 134 mmol) in DMSO (100 mL) were added at 10° C. to a solution of 1-benzhydrylazetidin-3-ol (5.0 g, 20.9 mmol) in DMSO (60 mL). The resulting mixture was stirred at 10° C. for 45 minutes, then at room temperature for 4 hours, subsequently quenched by pouring onto crushed ice (˜200 g) and extracted with ethyl acetate (3×200 mL). The combined organic layers were washed with water (400 mL) and brine (400 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (80:20 to 70:30) as eluent. The title product was obtained as a yellowish solid (4.35 g, 88%).

Quelle