Reaktion #1702337

ord-5969ccb1707f45ba95fc44edb647bb70

Reaktionsgleichung

CC1(C)COC2(CCC(O)(CC=O)CC2)OC1
(9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde
CC[C@H](N)c1ccccc1
(S)-1-phenyl-propylamine
CC[C@H](NCCC1(O)CCC2(CC1)OCC(C)(C)CO2)c1ccccc1
title compound
Ausbeute 50.0%
CC[C@H](NCCC1(O)CCC2(CC1)OCC(C)(C)CO2)c1ccccc1
3,3-Dimethyl-9-{2-[(S)-1-phenyl-propylamino]-ethyl}-1,5-dioxa-spiro[5.5]undecan-9-ol
Ausbeute 50.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-phenyl-propylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 50% of theory; LC (method 8): tR=1.16 min; Mass spectrum (ESI+): m/z=362 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08765744B2uspto-grants-2014_07