Reaktion #170227

Reaktionsgleichung

1-Chloroethyl chloroformate

1-benzhydryl-3-(benzo[b]thiophen-2-ylmethoxy)-azetidine

Methanol

→

title compound

3-(Benzo[b]thiophen-2-ylmethoxy)-azetidine hydrochloride

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture was stirred for an additional 16 hours at room temperature
2. 2
   EinengenThe reaction mixture was then concentrated to dryness
3. 3
   Sonstigethe residue was triturated in petroleum ether (20 mL)

Vorschrift

1-Chloroethyl chloroformate (322 μL, 1.1 mmol) was added to a solution of 1-benzhydryl-3-(benzo[b]thiophen-2-ylmethoxy)-azetidine (1.04 g, 2.7 mmol) in dichloromethane (17 mL) at room temperature. The reaction mixture was stirred for 2 hours. Methanol (17 mL) was added and the reaction mixture was stirred for an additional 16 hours at room temperature. The reaction mixture was then concentrated to dryness and the residue was triturated in petroleum ether (20 mL) to afford the title compound as a yellow solid (600 mg, 90%).

Quelle