Reaktion #170164

Reaktionsgleichung

1-Chloroethylchloroformate

1-benzhydryl-3-(2-(thiophen-2-yl)ethoxy)azetidine

ethanol

→

3-(2-(Thiophen-2-yl)ethoxy)azetidine hydrochloride

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige1 hour
2. 2
   Sonstigeat 70° C
3. 3
   TemperaturAfter cooling down to room temperature
4. 4
   workup.STIRRINGthe reaction mixture was stirred at 70° C. for 1 hour
5. 5
   EinengenAfter concentration to dryness
6. 6
   Sonstigethe crude mixture was triturated in pentane (2×15 mL)
7. 7
   Sonstigeto give a yellow oil (698 mg, quantitative) which
8. 8
   Sonstigewas used in the next step without further purification

Vorschrift

1-Chloroethylchloroformate (361 μL, 3.33 mmol) was added to a solution of 1-benzhydryl-3-(2-(thiophen-2-yl)ethoxy)azetidine (1.11 g, 3.17 mmol) in dichloromethane (15 mL) at room temperature. The reaction mixture was stirred overnight at room temperature, then 1 hour at 70° C. After cooling down to room temperature, ethanol (15 mL) was added and the reaction mixture was stirred at 70° C. for 1 hour. After concentration to dryness, the crude mixture was triturated in pentane (2×15 mL) to give a yellow oil (698 mg, quantitative) which was used in the next step without further purification.

Quelle