Reaktion #170162

Reaktionsgleichung

Triethylamine

mesyl chloride

1-benzhydrylazetan-3-ol

water

→

title compound

1-Benzhydrylazetidin-3-yl methanesulfonate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe aqueous phase was separated
2. 2
   Extraktionextracted with dichloromethane (2×40 mL)
3. 3
   WaschenThe combined organic phases were washed with a saturated solution of sodium chloride (40 mL)
4. 4
   Trocknendried over sodium sulfate
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated to dryness

Vorschrift

Triethylamine (870 ml, 62.67 mmol) and mesyl chloride (390 μL, 50.13 mmol) were successively added to a solution of 1-benzhydrylazetan-3-ol (1.0 g, 41.78 mmol) in dichloromethane (10 mL) at room temperature. The reaction mixture was stirred for 1 hour and then diluted by addition of water (20 mL). The aqueous phase was separated and extracted with dichloromethane (2×40 mL). The combined organic phases were washed with a saturated solution of sodium chloride (40 mL), dried over sodium sulfate, filtered and concentrated to dryness. The title compound was obtained as a yellow solid (1.5 g, 100%).

Quelle