Reaktion #170135

Reaktionsgleichung

tert-butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate

tert-Butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate

HCl

→

title compound

2-[(Azetidin-3-yloxy)methyl]-1,3-thiazole hydrochloride

Lösungsmittel

diethyl ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthen concentrated to dryness
2. 2
   SonstigeThe resulting solid was triturated with diethyl ether
3. 3
   Sonstigecollected
4. 4
   Sonstigedried

Vorschrift

To a solution of tert-butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate (193 mg, 0.71 mmol; which may be prepared as described in Step 2) dissolved in diethyl ether (2.6 mL) at room temperature was added HCl 2N in diethyl ether (7.1 mL). The reaction mixture was stirred for 1.5 h then concentrated to dryness. The resulting solid was triturated with diethyl ether, collected and dried to give the title compound (138 mg, quantitative) as a brown oil.

Quelle