Reaktion #170134

Reaktionsgleichung

2-(chloromethyl)-1,3-thiazol-3-ium chloride

2-(Chloromethyl)-1,3-thiazol-3-ium chloride

N-Boc-azetidin-3-ol

NaH

→

product

Ausbeute 48.0%

tert-Butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate

Ausbeute 48.0%

Lösungsmittel

DIPEA

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to room temperature
2. 2
   Temperaturthen heated to 80° C. overnight
3. 3
   TemperaturThe reaction mixture was cooled
4. 4
   Einengenthe mixture concentrated under reduced pressure
5. 5
   SonstigeThe crude material was purified on column chromatography (eluent: Pentane/EtOAc, 90/10 to 50/50)

Vorschrift

To a solution of N-Boc-azetidin-3-ol (260 mg, 1.5 mmol) in DMF (3.5 mL) at 0° C. under nitrogen was added NaH (60% in oil, 126 mg, 3.15 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with 2-(chloromethyl)-1,3-thiazol-3-ium chloride (510 mg, 3.0 mmol; which may be prepared as described in Step 1) dissolved in DMF (1 mL) and DIPEA (1.05 mL). The mixture was allowed to warm to room temperature then heated to 80° C. overnight. The reaction mixture was cooled, water (20 drops) was added and the mixture concentrated under reduced pressure. The crude material was purified on column chromatography (eluent: Pentane/EtOAc, 90/10 to 50/50) to give the product (193 mg, 48%) as a brown oil.

Quelle