Reaktion #170096

Reaktionsgleichung

1-diphenylmethylazetidin-3-ol

methane sulfonyl chloride

→

title compound

Ausbeute 96.5%

1-(Diphenylmethyl)azetidin-3-yl methanesulfonate

Ausbeute 96.5%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITleft 3 days at 4° C
2. 2
   workup.ADDITIONThe solution was poured on ice
3. 3
   Filtrationthe resulting precipitate was filtered
4. 4
   Waschenwashed 3 times with H2O and 3 times with pentane
5. 5
   SonstigeThe solid was dried under reduced pressure

Vorschrift

A 100 mL flask was charged with 1-diphenylmethylazetidin-3-ol (1.5 g, 6.27 mmol) and pyridine (15 mL). The solution was cooled to −20° C. and methane sulfonyl chloride (0.73 mL, 9.4 mmol) was added dropwise. The reaction mixture was stirred at −20° C. for 1 h and then left 3 days at 4° C. The solution was poured on ice and the resulting precipitate was filtered, washed 3 times with H2O and 3 times with pentane. The solid was dried under reduced pressure to give the title compound (1.92 g, 96%) as a white solid.

Quelle