Reaktion #170087

Reaktionsgleichung

2-amino-5-bromo-3-(hydroxymethyl)pyridine

hydrobromic acid

→

title product

2-Amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux overnight
2. 2
   Filtrationthe precipitated product filtered
3. 3
   Waschenwashed with H2O (100 mL)
4. 4
   Sonstigedried

Vorschrift

A solution of 2-amino-5-bromo-3-(hydroxymethyl)pyridine (34.6 g, 170.0 mmol) in hydrobromic acid (48% in H2O, 93 mL) was stirred at reflux overnight. The reaction mixture was cooled to room temperature, the precipitated product filtered and washed with H2O (100 mL) and dried. The title product was obtained as a light yellow solid (36.1 g, 56%, py 96.5%).

Quelle