Reaktion #170050

Reaktionsgleichung

tert-Butyl 1-benzyl-7-(ethylsulfonamidomethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

trifluoroacetic acid

→

N-((7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)ethanesulfonamide

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution was evaporated
2. 2
   Sonstigepartitioned between saturated aqueous NaHCO3 and ethyl acetate
3. 3
   ExtraktionWater was extracted with ethyl acetate (2×30 mL)
4. 4
   SonstigeThe collected organic extracts were dried on MgSO4
5. 5
   Sonstigeevaporated under reduced pressure
6. 6
   Sonstigeto give a brown oil

Vorschrift

tert-Butyl 1-benzyl-7-(ethylsulfonamidomethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (0.652 g, 1.422 mmol) was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (0.5 mL, 6.49 mmol) and stirred overnight at room temperature. The solution was evaporated and partitioned between saturated aqueous NaHCO3 and ethyl acetate. Water was extracted with ethyl acetate (2×30 mL). The collected organic extracts were dried on MgSO4 and evaporated under reduced pressure to give a brown oil.

Quelle