Reaktion #169966

Reaktionsgleichung

SOCl2

2,6-difluoro-4-hydroxybenzoic acid

MeOH

→

title compound

Ausbeute 99.0%

Methyl 2,6-difluoro-4-hydroxybenzoate

Ausbeute 99.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe resulting mixture was heated
2. 2
   Temperaturat reflux for 24 h
3. 3
   TemperaturAfter cooling the solvent
4. 4
   Sonstigewas removed in vacuo

Vorschrift

SOCl2 (4.16 g, 30.1 mmol) was added to a solution of 2,6-difluoro-4-hydroxybenzoic acid (1.50 g, 8.62 mmol) in MeOH (20 mL) and the resulting mixture was heated at reflux for 24 h. After cooling the solvent was removed in vacuo to give the title compound (1.62 g, 99%) as a white crystalline solid; mp 177.5-180° C.; 1H NMR (270 MHz, DMSO-d6) 3.80 (3H, s, CH3), 6.50-6.60 (2H, m, ArH), 11.16 (1H, s, OH)

Quelle