Reaktion #169952

ord-7f3bc86191574f4e9bab7596a51946d1

Reaktionsgleichung

CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(=O)O
(2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
N
NH3
→
CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1CO
title compound
CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1CO
(2S,4R)-tert-butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Edukte

CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(=O)O
(2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
N
NH3

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared as described in Example 53A substituting (2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid for (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid. MS (DCI/NH3) m/z 220 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846730B2uspto-grants-2014_09