Reaktion #169863

ord-412c570017f64e2980db3aa767af1939

Reaktionsgleichung

CCOC(=O)Cn1c(Cl)nc2cccnc21
ethyl (2-chloro-3H-imidazo[4,5-b]pyridin-3-yl)acetate
Nc1ccc([N+](=O)[O-])cc1
4-nitroaniline
→
CCOC(=O)Cn1c(Nc2ccc([N+](=O)[O-])cc2)nc2cccnc21
title compound
Ausbeute 101.2%
CCOC(=O)Cn1c(Nc2ccc([N+](=O)[O-])cc2)nc2cccnc21
ethyl {2-[(4-nitrophenyl)amino]-3H-imidazo[4,5-b]pyridin-3-yl}acetate
Ausbeute 101.2%

Edukte

CCOC(=O)Cn1c(Cl)nc2cccnc21
ethyl (2-chloro-3H-imidazo[4,5-b]pyridin-3-yl)acetate
Nc1ccc([N+](=O)[O-])cc1
4-nitroaniline

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
150°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A mixture of ethyl (2-chloro-3H-imidazo[4,5-b]pyridin-3-yl)acetate (2.8 g) and 4-nitroaniline (1.6 g) was stirred at 150° C. for 1 h to give the title compound (4.0 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846713B2uspto-grants-2014_09