Reaktion #1696838

Reaktionsgleichung

5-benzyloxy-2-hydroxymethyl-4-pyridone

thionyl chloride

→

5-benzyloxy-2-chloromethyl-4-pyridone

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter being stirred at the same temperature for 30 minutes
2. 2
   Temperaturthe mixture was refluxed for 4 hours
3. 3
   FiltrationThe precipitate was collected by filtration
4. 4
   Waschenwashed with benzene
5. 5
   Sonstigedried under reduced pressure

Vorschrift

To a suspension of 5-benzyloxy-2-hydroxymethyl-4-pyridone (33 g) in benzene (500 ml) was added thionyl chloride (28.4 ml) at ambient temperature under stirring. After being stirred at the same temperature for 30 minutes, the mixture was refluxed for 4 hours. The resulting mixture was cooled to ambient temperature. The precipitate was collected by filtration, washed with benzene and dried under reduced pressure to give 5-benzyloxy-2-chloromethyl-4-pyridone (41.5 g).

Quelle