Reaktion #169612

Reaktionsgleichung

potassium carbonate

triethylamine

benzofuran-2-carboxylic acid

(2S,3R)-3-amino-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octane

→

(2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octan-3-yl)benzofuran-2-carboxamide

Ausbeute 77.0%

Lösungsmittel

Dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a mechanical stirrer under an inert atmosphere
2. 2
   workup.ADDITIONwas added to the reaction mixture
3. 3
   workup.STIRRINGthe mixture was stirred for a minimum of 5 min
4. 4
   SonstigeThe layers were separated
5. 5
   Waschenthe organic phase was washed with 10% brine (12.7 L)
6. 6
   SonstigeThe layers were separated
7. 7
   Temperaturthe organic phase was cooled to 15° C.±10° C
8. 8
   workup.ADDITION3 M Hydrochloric acid (8.0 L) was slowly added to the reaction mixture
9. 9
   workup.STIRRINGThe mixture was then stirred for a minimum of 5 min
10. 10
    Sonstigeto partition for a minimum of 5 min
11. 11
    FiltrationThe solids were filtered
12. 12
    SonstigeThe layers of the filtrate were separated
13. 13
    workup.ADDITION3 M Sodium hydroxide (9.0 L) was slowly added to the flask in portions
14. 14
    ExtraktionThe aqueous phase was extracted with dichloromethane (2×16.5 L)
15. 15
    TrocknenThe combined organic phases were dried over anhydrous sodium sulfate (1.71 kg)
16. 16
    FiltrationThe mixture was filtered
17. 17
    Einengenthe filtrate was concentrated

Vorschrift

The (2S,3R)-3-amino-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octane was transferred to a 50 L glass reaction flask equipped with a mechanical stirrer under an inert atmosphere. Dichloromethane (16.5 L), triethylamine (847 mL, 6.08 mol), benzofuran-2-carboxylic acid (948 g, 5.85 mol) and O-(benzotriazol-1-yl)-N,N,N,1-tetramethyluronium hexafluorophosphate (HBTU) (2.17 kg, 5.85 mol) were added to the reaction mixture. The mixture was stirred for a minimum of 4 h at ambient temperature, and the reaction was monitored by HPLC. Upon completion of the reaction, 10% aqueous potassium carbonate (12.7 L, 17.1 mol) was added to the reaction mixture and the mixture was stirred for a minimum of 5 min. The layers were separated and the organic phase was washed with 10% brine (12.7 L). The layers were separated and the organic phase was cooled to 15° C.±10° C. 3 M Hydrochloric acid (8.0 L) was slowly added to the reaction mixture to adjust the pH of the mixture to pH 1. The mixture was then stirred for a minimum of 5 min, and the layers were allowed to partition for a minimum of 5 min. The solids were filtered using a table top filter. The layers of the filtrate were separated, and the aqueous phase and the solids from the funnel were transferred to the reaction flask. 3 M Sodium hydroxide (9.0 L) was slowly added to the flask in portions to adjust the pH of the mixture to pH 14. The aqueous phase was extracted with dichloromethane (2×16.5 L). The combined organic phases were dried over anhydrous sodium sulfate (1.71 kg). The mixture was filtered, and the filtrate was concentrated to give (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octan-3-yl)benzofuran-2-carboxamide (1.63 kg, 77.0% yield) as a yellow solid.

Quelle