Reaktion #169605

Reaktionsgleichung

ammonium formate

2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octan-3-one

ether

sodium cyanoborohydride

→

3-Amino-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octane

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter stirring another hour at ambient temperature
2. 2
   workup.STIRRINGThe reaction was then stirred at ambient temperature overnight
3. 3
   Sonstigeterminated by addition of water (˜5 mL)
4. 4
   SonstigeThe quenched reaction
5. 5
   Sonstigewas partitioned between 5 M sodium hydroxide (10 mL) and chloroform (20 mL)
6. 6
   ExtraktionThe aqueous layer was extracted with chloroform (20 mL)
7. 7
   Trocknenwere dried (sodium sulfate)
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated
10. 10
    workup.ADDITIONa 1:9 mixture of the cis and trans amines

Vorschrift

To a stirred solution of 2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octan-3-one (3.00 g, 13.9 mmol) in dry methanol (20 mL), under nitrogen, was added a 1 M solution of zinc chloride in ether (2.78 mL, 2.78 mmol). After stirring at ambient temperature for 30 min, this mixture was treated with solid ammonium formate (10.4 g, 167 mmol). After stirring another hour at ambient temperature, solid sodium cyanoborohydride (1.75 g, 27.8 mmol) was added in portions. The reaction was then stirred at ambient temperature overnight and terminated by addition of water (˜5 mL). The quenched reaction was partitioned between 5 M sodium hydroxide (10 mL) and chloroform (20 mL). The aqueous layer was extracted with chloroform (20 mL), and combined organic layers were dried (sodium sulfate), filtered and concentrated. This left 2.97 g of yellow gum. GCMS analysis indicated that the product was a 1:9 mixture of the cis and trans amines, along with a trace of the corresponding alcohol (98% total mass recovery).

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