Reaktion #1696019

Reaktionsgleichung

2-amino-N-[2-(1H-imidazol-2-yl)ethyl]benzamide

meta-t-butylbenzoyl chloride

diethyl ether

→

titled compound

N-[2-(1H-Imidazol-2-yl)ethyl]-2-[[3-(1,1-dimethylethyl)-benzoyl]amino]benzamide

Lösungsmittel

methanol ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe resulting solution was concentrated until crystals
2. 2
   Sonstigeto form
3. 3
   TemperaturThe resulting solution was cooled
4. 4
   Filtration2.90 g of the desired titled compound were recovered by filtration (m.p. 205°-210° C.)

Vorschrift

The titled compound was prepared substantially in accordance with the method detailed in Example 46 using 2.50 g (0.0107 mol) of 2-amino-N-[2-(1H-imidazol-2-yl)ethyl]benzamide and 4.20 g (0.0213 mol) of meta-t-butylbenzoyl chloride with the exception that, after reducing the organic layer to dryness the resulting residue was dissolved in a 1:7 methanol/ethyl acetate solution. The resulting solution was concentrated until crystals began to form and then diethyl ether was added. The resulting solution was cooled and 2.90 g of the desired titled compound were recovered by filtration (m.p. 205°-210° C.).

Quelle