Reaktion #1695813

Reaktionsgleichung

5-[1-(methylsulfonyl)-4-piperidyloxy]-3-nitroimidazo[1,2-a]pyridine

→

desired product

Ausbeute 132.6%

3-amino-5-[1-(methylsulfonyl)-4-piperidyloxy]imidazo[1,2-a]pyridine

Ausbeute 132.6%

Lösungsmittel

methylene chloride

hydrogen

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the reaction mixture was treated with Cellite
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   workup.ADDITIONTo the residue was added chloroform, which
4. 4
   Waschenwas washed in turn with an aqueous saturated sodium bicarbonate solution and water
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONAfter the solvent was distilled off
7. 7
   Sonstigethe residue was purified by column chromatography [eluent: chloroform/methanol (15:1)]

Vorschrift

To a solution of 5-[1-(methylsulfonyl)-4-piperidyloxy]-3-nitroimidazo[1,2-a]pyridine (70 mg, 0.226 mmole) in methylene chloride (10 ml) was added 10% palladium-carbon (50 ml) and the mixture was stirred in hydrogen atmosphere at room temperature for 1.5 hours. After the reaction mixture was treated with Cellite, the solvent was distilled off. To the residue was added chloroform, which was washed in turn with an aqueous saturated sodium bicarbonate solution and water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography [eluent: chloroform/methanol (15:1)] to obtain 93 mg of the desired product (30.0%, brown oily product).

Quelle