Reaktion #1695811

ord-eded28059550451b99e2043056287a5a

Reaktionsgleichung

CC(C)(C)OC(=O)NCCSc1cccc2ncc([N+](=O)[O-])n12
5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine
Cl
hydrochloric acid
→
Cl.Cl.NCCSc1cccc2ncc([N+](=O)[O-])n12
desired product
Cl.Cl.NCCSc1cccc2ncc([N+](=O)[O-])n12
5-[2-(amino)ethylthio]-3-nitroimidazo[1,2-a]pyridine,dihydrochloride

Edukte

CC(C)(C)OC(=O)NCCSc1cccc2ncc([N+](=O)[O-])n12
5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine
Cl
hydrochloric acid

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISTILLATIONThen, the solvent was distilled off

Vorschrift

To a suspension of 5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine (364 mg, 1.08 mmoles) in methanol (3 ml) was added conc. hydrochloric acid (2 ml) and the mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off to obtain 340 mg of the desired product (quantitative, brown solid).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05395839uspto-grants-1995_03