Reaktion #169519

Reaktionsgleichung

(2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile

KOH

MTBE

→

(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled
2. 2
   WaschenThe organic phase is washed with water and brine
3. 3
   Sonstigethe solvent is removed

Vorschrift

A mixture of (2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile (1.0 eq), 50 wt % aqueous KOH (5.0 eq) 1-bromo-2-chloroethane (1.5 eq), and Oct4NBr (0.02 eq) is heated at 70° C. for 1 h. The reaction mixture is cooled then worked up with MTBE and water. The organic phase is washed with water and brine then the solvent is removed to afford (2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile.

Quelle