Reaktion #169470

Reaktionsgleichung

(4-nitro-phenyl)-acetic acid ethyl ester

→

title compound

Ausbeute 96.0%

(4-Amino-phenyl)-acetic acid ethyl ester

Ausbeute 96.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through celite
2. 2
   Waschenwashed with methanol (2×20 mL)
3. 3
   Sonstigethe filtrate was evaporated in vacuo

Vorschrift

A solution of (4-nitro-phenyl)-acetic acid ethyl ester (Preparation 266, 3.4 g, 16.1 mmol) in methanol (100 mL) was degassed with argon for 15 min, treated with 10% palladium on charcoal (700 mg), and then stirred at room temperature under hydrogen (balloon pressure) for 16 hours. The reaction mixture was filtered through celite, washed with methanol (2×20 mL) and the filtrate was evaporated in vacuo to afford the title compound as an oil in 96% yield, 2.8 g.

Quelle