Reaktion #169469

Reaktionsgleichung

NaOH

(4-nitro-phenyl)-acetic acid

sulphuric acid

ethanol

→

title compound

Ausbeute 98.0%

(4-Nitro-phenyl)-acetic acid ethyl ester

Ausbeute 98.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture was heated
2. 2
   Temperaturto reflux for 16 hours
3. 3
   Extraktionextracted with EtOAc (3×50 mL)
4. 4
   TrocknenThe combined organic layers were dried (Na2SO4)
5. 5
   Sonstigeevaporated in vacuo

Vorschrift

To a stirred solution of (4-nitro-phenyl)-acetic acid (3 g, 16.4 mmol) in ethanol (30 mL) was added sulphuric acid (1 mL) and the reaction mixture was heated to reflux for 16 hours. The reaction mixture was neutralized with 2N aq. NaOH solution and extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a light yellow oil in 98% yield, 3.4 g.

Quelle