Reaktion #169447

Reaktionsgleichung

Bromine

6-Hydroxy-nicotinic acid

→

title compound

Ausbeute 82.0%

5-Bromo-6-hydroxy-nicotinic acid

Ausbeute 82.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated solid was filtered
2. 2
   Waschenwashed with cold water
3. 3
   Sonstigedried

Vorschrift

Bromine (3.6 mL, 70.5 mmol) was added dropwise to a suspension of 6-Hydroxy-nicotinic acid (7 g, 50.32 mmol) in water (70 mL) at 00° C. and the mixture was stirred at room temperature for 4 hours. The precipitated solid was filtered, washed with cold water and dried to get the title compound as off white solid in 82% yield, 9 g.

Quelle