Reaktion #1694409

ord-0f6de54fdbe14f2698a674234a5b5c00

Reaktionsgleichung

COC(=O)C1(C)CNN=C1c1ccc(Cl)cc1
3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole
O=C=Nc1ccc(C(F)(F)F)cc1
4-trifluoromethylphenyl isocyanate
→
COC(=O)C1(C)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)N=C1c1ccc(Cl)cc1
N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide
Ausbeute 95.0%

Edukte

COC(=O)C1(C)CNN=C1c1ccc(Cl)cc1
3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole
O=C=Nc1ccc(C(F)(F)F)cc1
4-trifluoromethylphenyl isocyanate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole (Example O) and 4-trifluoromethylphenyl isocyanate were reacted by substantially following the procedure given in Example D to give a 95% yield of N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide. NMR data was consistent with the structure.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04863947uspto-grants-1989_09