Reaktion #169335

ord-0d42c5b1f37e4d2c8fb549d91a250d51

Reaktionsgleichung

C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(N)c2)c2cncnc21
(5-aminopyridin-3-yl){7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone
O=C(O)Cn1nc2ccccc2n1
benzotriazol-2-yl-acetic acid
→
C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(NC(=O)Cn3nc4ccccc4n3)c2)c2cncnc21
title compound
C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(NC(=O)Cn3nc4ccccc4n3)c2)c2cncnc21
2-(2H-Benzotriazol-2-yl)-N-[5-({7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]acetamide

Edukte

C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(N)c2)c2cncnc21
(5-aminopyridin-3-yl){7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone
O=C(O)Cn1nc2ccccc2n1
benzotriazol-2-yl-acetic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe title compound was prepared

Vorschrift

The title compound was prepared according to the method described for Example 1 using (5-aminopyridin-3-yl){7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (see Preparation 33) and benzotriazol-2-yl-acetic acid to afford the title compound as a yellow solid in 72% yield, 70 mg.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846698B2uspto-grants-2014_09