Reaktion #169220

Reaktionsgleichung

4-iodo-benzoyl chloride

piperidine

→

title compound

Ausbeute 100.1%

(4-iodo-phenyl)-piperidin-1-yl-methanone

Ausbeute 100.1%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturat reflux for 1.5 hour
3. 3
   WaschenThe organic layer was washed with an aqueous 1M HCl solution, brine
4. 4
   Trocknendried (Na2SO4)
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated under vacuum

Vorschrift

To a suspension of 4-iodo-benzoyl chloride (2.00 g, 7.51 mmol) in dichloromethane (25 mL) was added piperidine (1.85 mL, 18.76 mmol). The reaction mixture was heated at reflux for 1.5 hour and then cooled to room temperature. The organic layer was washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (2.37 g, 100%) as a white solid.

Quelle