Reaktion #1691071

Reaktionsgleichung

5-bromo-2-benzofurancarboxylic acid

sulfuric acid

ethanol

→

title compound

Ausbeute 93.0%

Ethyl 5-bromo-2-benzofurancarboxylate

Ausbeute 93.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed
2. 2
   SonstigeAfter this time, the volatiles were evaporated off under reduced pressure
3. 3
   Extraktionextracted with ethyl ether (4×100 ml)
4. 4
   SonstigeThe mixture was dried
5. 5
   Sonstigethe solvent was evaporated off under reduced pressure

Vorschrift

A solution of 5-bromo-2-benzofurancarboxylic acid (5.01 g, 20.8 mmol) in absolute ethanol (150 ml) was added with concentrated sulfuric acid (15 ml) and the mixture was refluxed under stirring for 2 h. After this time, the volatiles were evaporated off under reduced pressure and the resulting residue was neutralized with a sodium bicarbonate saturated solution and extracted with ethyl ether (4×100 ml). The mixture was dried and the solvent was evaporated off under reduced pressure, to obtain 5.19 g of the title compound as a white solid with melting point 58-60° C. (93% yield).

Quelle