Reaktion #1690032

Reaktionsgleichung

4,5-Methylenedioxysalicylic acid

carbonyldiimidazole

2-amino-1-propanol

→

2-(2-hydroxy-4,5-methylenedioxybenzamido)-1-propanol

Ausbeute 52.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAn acidic quench
2. 2
   Sonstigesubsequent purification by flash chromatography (SiO2)

Vorschrift

4,5-Methylenedioxysalicylic acid was activated by carbonyldiimidazole in methylene chloride and combined with 2-amino-1-propanol in essentially an identical manner as for Example 1 above. An acidic quench and subsequent purification by flash chromatography (SiO2) using (1:1) hexane-ethyl acetate gave 2-(2-hydroxy-4,5-methylenedioxybenzamido)-1-propanol as a waxy white solid in 52% yield.

Quelle