Reaktion #168909

ord-11baf50cb9d640ed8ce2abccff348c0b

Reaktionsgleichung

NCc1cccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1
4-(3-(aminomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine
C=CC(=O)O
acrylic acid
→
C=CC(=O)NCc1cccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1
product
Ausbeute 31.3%
C=CC(=O)NCc1cccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1
N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)benzyl)acrylamide
Ausbeute 31.3%

Edukte

NCc1cccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1
4-(3-(aminomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine
C=CC(=O)O
acrylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a procedure analogous to Example 15, reaction of 4-(3-(aminomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (60 mg, 0.15 mmol) and acrylic acid (16 mg, 0.23 mmol) furnished the product (21 mg, 31%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846704B2uspto-grants-2014_09