Reaktion #168905

ord-f0bb824a1fb6406f97dae467c27d0898

Reaktionsgleichung

NSc1ccc(-c2ccnc(Cl)n2)cc1.Nc1ccc(Sc2ccnc(Cl)n2)cc1
4-(2-chloropyrimidin-4-ylthio)benzenamine 2-chloro-4-(4′-aminothiophenyl)pyrimidine
C=CC(=O)O
acrylic acid
→
C=CC(=O)Nc1ccc(Sc2ccnc(Cl)n2)cc1
product
Ausbeute 56.0%
C=CC(=O)Nc1ccc(Sc2ccnc(Cl)n2)cc1
N-(4-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide
Ausbeute 56.0%

Edukte

NSc1ccc(-c2ccnc(Cl)n2)cc1.Nc1ccc(Sc2ccnc(Cl)n2)cc1
4-(2-chloropyrimidin-4-ylthio)benzenamine 2-chloro-4-(4′-aminothiophenyl)pyrimidine
C=CC(=O)O
acrylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a procedure analogous to Example 15, reaction of 4-(2-chloropyrimidin-4-ylthio)benzenamine 2-chloro-4-(4′-aminothiophenyl)pyrimidine (800 mg, 3.37 mmol) and acrylic acid (463 μL, 6.74 mmol) furnished the product (550 mg, 56%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846704B2uspto-grants-2014_09