Reaktion #1689

Reaktionsgleichung

HCl

phenethylamine

triethylamine

methyl chloroformate

→

title compound

Ausbeute 95.0%

N-Methoxycarbonylphenethylamine

Ausbeute 95.0%

Lösungsmittel

diethyl ether

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic layer was washed with water
2. 2
   Trocknendried (MgSO4)
3. 3
   Filtrationfiltered
4. 4
   Einengenthe filtrate was concentrated in vacuo

Vorschrift

To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).

Quelle