Reaktion #168895

ord-c6ab1dea59d649a9957a355da4620c12

Reaktionsgleichung

C=CC(=O)Nc1cccc(Sc2ccnc(Cl)n2)c1
N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide
COc1cc(N)cc(OC)c1OC
3,4,5-trimethoxyaniline
→
C=CC(=O)Nc1cccc(Sc2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)c1
product
Ausbeute 14.0%
C=CC(=O)Nc1cccc(Sc2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)c1
N-(3-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
Ausbeute 14.0%

Edukte

C=CC(=O)Nc1cccc(Sc2ccnc(Cl)n2)c1
N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide
COc1cc(N)cc(OC)c1OC
3,4,5-trimethoxyaniline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a procedure analogous to Example 8, reaction of N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide (100 mg, 0.34 mmol) and 3,4,5-trimethoxyaniline (75 mg, 0.41 mmol) furnished the product (20 mg, 14%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846704B2uspto-grants-2014_09