Reaktion #1687635

ord-1f3d63b3d76045508493ba53e1f22655

Reaktionsgleichung

O=C([O-])/C=C/C(=O)[O-]
fumarate
Cc1cnc(-c2cccnc2)s1
88
Cc1cnc(-c2cccnc2)s1
5-Methyl-2-(3-pyridyl)-thiazole
→
Cc1cnc(C2=CCCN(C)C2)s1
title compound
Cc1cnc(C2=CCCN(C)C2)s1
5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

Edukte

O=C([O-])/C=C/C(=O)[O-]
fumarate
Cc1cnc(-c2cccnc2)s1
88
Cc1cnc(-c2cccnc2)s1
5-Methyl-2-(3-pyridyl)-thiazole
—
(C12H16N2O2S)C

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude free base obtained

Vorschrift

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE036374uspto-grants-1999_11