Reaktion #1687629

Reaktionsgleichung

73

N-Acetylmethyl-nicotinamide

ammonia

→

74

5-Methyl-2-(3-pyridyl)-oxazole

Lösungsmittel

sulphuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the mixture
2. 2
   workup.ADDITIONwas poured over ice
3. 3
   ExtraktionExtraction with 3×400 ml of dichloromethane
4. 4
   Trocknendrying of the combined organic phase over magnesium sulphate, and removal of the solvent in vacuo

Vorschrift

A mixture of 20 g (0.110 mol) of 73 and 100 ml of conc. sulphuric acid was heated to 120° C. for 4 h. After cooling the mixture was poured over ice followed by basification with ammonia. Extraction with 3×400 ml of dichloromethane, drying of the combined organic phase over magnesium sulphate, and removal of the solvent in vacuo gave crude 74 as a red oil, which was sufficiently pure. Yield: 17 g (0.100 mol, 97%).

Quelle