Reaktion #1687309

Reaktionsgleichung

product

(+/-)-Ethanethioic acid S-[5-(2,4-difluorophenyl)tetrahydro-3-furanyl]ester

sodium methoxide methyl alcohol

tetrahydrofuran

hydrochloric acid isopropyl alcohol

→

desired product

5-(2,4-Difluorophenyl)tetrahydro-3-furanthiol

Lösungsmittel

ethyl acetate hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto give

Vorschrift

The title compound is prepared by the procedure of Example 16 using 0.250 gof product from Example 166, 243 μl of 25% sodium methoxide/methyl alcohol, 4.5 ml of tetrahydrofuran and 530 μl of 2N hydrochloric acid/isopropyl alcohol to give, after chromatography (silica gel: 5-10% ethyl acetate/hexane), 0.180 g of the desired product, as a mixture of isomers.

Quelle