Reaktion #168666

Reaktionsgleichung

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride

morphline

→

title compound

4-(5-chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

Lösungsmittel

DCM

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 0.1M HCl
2. 2
   Trocknendried (MgSO4)
3. 3
   Einengenconcentrated in vacuo

Vorschrift

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride (0.17 g, 0.62 mmol) is added to a solution of morphline (0.114 ml, 1.3 mol) in DCM (5 ml) and the resulting white suspension is stirred at room temperature overnight. The reaction mixture is diluted with DCM (5 ml), and washed with 0.1M HCl, dried (MgSO4) and concentrated in vacuo to yield the title compound. [M+H]+ 330.

Quelle