Reaktion #1686166

Reaktionsgleichung

methyl 6-methoxy-1,3-benzodioxole-5-carboxylate

sodium hydroxide

ethanol

→

6-methoxy-1,3-benzodioxole-5-carboxylic acid

Ausbeute 85.7%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated 1 hour
2. 2
   Temperaturat reflux
3. 3
   Waschenwashed with diethyl ether (2×)
4. 4
   workup.ADDITIONtreated with concentrated hydrochloric acid
5. 5
   Temperaturcooled in an ice-bath
6. 6
   SonstigeThe solids were collected
7. 7
   Waschenwashed with water (2×)
8. 8
   Sonstigedried under vacuum at 70° C.

Vorschrift

A mixture of methyl 6-methoxy-1,3-benzodioxole-5-carboxylate (3 g, 14 mmol), prepared as in Example 1, 20% sodium hydroxide (50 mL) and ethanol (25 mL) was heated 1 hour at reflux and then diluted with water, washed with diethyl ether (2×), treated with concentrated hydrochloric acid and cooled in an ice-bath. The solids were collected, washed with water (2×) and dried under vacuum at 70° C. to give 6-methoxy-1,3-benzodioxole-5-carboxylic acid (2.3 g, 12 mmol), m.p. 151° C.

Quelle