Reaktion #1681710

ord-e2edfb3bf34348ae91b0ec94c5686ac9

Reaktionsgleichung

CN(C)CC1CCC(C(F)(F)F)CC1=O
(2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone
O=C1CCCC(C(F)(F)F)C1
3-trifluoromethyl-cyclohexanone
CN(C)C(Cl)Cl
dimethylaminomethylene chloride
→
CN(C)CC1CCC(C(F)(F)F)CC1(O)c1cccc(O)c1.Cl
( 27 )
CN(C)CC1CCC(C(F)(F)F)CC1(O)c1cccc(O)c1.Cl
(1RS,2RS ,5RS)-3-(2-dimethylaminomethyl-1-hydroxy-5-trifluoromethyl-cyclohexyl)-phenol hydrochloride

Edukte

CN(C)CC1CCC(C(F)(F)F)CC1=O
(2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone
O=C1CCCC(C(F)(F)F)C1
3-trifluoromethyl-cyclohexanone
CN(C)C(Cl)Cl
dimethylaminomethylene chloride

Reagenzien

Keine

Lösungsmittel

CC#N
acetonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe 5-epimer (27) of compound (25) was prepared, under the conditions

Vorschrift

The 5-epimer (27) of compound (25) was prepared, under the conditions given in Example 27, from (2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone, prepared from 3-trifluoromethyl-cyclohexanone and dimethylaminomethylene chloride in acetonitrile. (27) was obtained in a yield of 27% theoretical and had a melting point of 221°-223° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE037355E1uspto-grants-2001_09