Reaktion #168163

Reaktionsgleichung

methanesulfonic acid 2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl ester

(S)-1-(4-bromophenyl)ethanamine

K2CO3

→

[(S)-1-(4-bromophenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Ausbeute 38.0%

Lösungsmittel

CH3CN

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 10 h
2. 2
   FiltrationThe solution was filtered
3. 3
   Einengenthe filtrate was concentrated
4. 4
   Sonstigeto afford the crude product, which
5. 5
   Sonstigewas purified by column chromatography

Vorschrift

To a solution of methanesulfonic acid 2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl ester (12 g, 50 mmol) and (S)-1-(4-bromophenyl)ethanamine (19.9 g, 100 mmol) in CH3CN (250 mL) was added K2CO3 (8 g, 58 mmol), and the mixture was refluxed for 10 h. The solution was filtered, and the filtrate was concentrated to afford the crude product, which was purified by column chromatography to give [(S)-1-(4-bromophenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine (6.5 g, 38%).

Quelle