Reaktion #168153

Reaktionsgleichung

MeSO2Cl

(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-3-[(S)-1-(4-piperidin-4-yl-phenyl)-ethyl]-[1,3]oxazinan-2-one

triethylamine

→

title compound

(S)-6-(2-Hydroxy-2-methyl-propyl)-3-{(S)-1-[4-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-ethyl}-6-phenyl-[1,3]oxazinan-2-one

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Waschenthe resulting solution was washed with aqueous NaHCO3 solution, water, and brine
3. 3
   TrocknenThe organic solution was then dried (MgSO4)
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was purified by HPLC on reversed phase (MeCN/H2O/NH3)

Vorschrift

MeSO2Cl (29 μL) was added to a solution of (S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-3-[(S)-1-(4-piperidin-4-yl-phenyl)-ethyl]-[1,3]oxazinan-2-one (150 mg) and triethylamine (100 μL) in dichloromethane (3 mL) at room temperature. After stirring the solution at room temperature overnight, more dichloromethane was added and the resulting solution was washed with aqueous NaHCO3 solution, water, and brine. The organic solution was then dried (MgSO4) and concentrated. The residue was purified by HPLC on reversed phase (MeCN/H2O/NH3) to afford the title compound.

Quelle