Reaktion #168129

Reaktionsgleichung

NEt3

(S)-1-(4-chloro-phenyl)-ethylamine

3-chloro-1-phenyl-propan-1-one

→

title compound

3-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThen, the solution was concentrated
2. 2
   workup.ADDITIONwater (100 mL) was added to the residue
3. 3
   Extraktionthe resulting mixture was extracted with tert-butyl methyl ether
4. 4
   WaschenThe combined organic extracts were washed with water and brine
5. 5
   Trocknendried (MgSO4)

Vorschrift

NEt3 (60 mL) followed by (S)-1-(4-chloro-phenyl)-ethylamine (20.5 g) was added to a solution of 3-chloro-1-phenyl-propan-1-one (23.2 g) in tetrahydrofuran (200 mL). The resulting mixture was stirred at room temperature overnight. Then, the solution was concentrated, water (100 mL) was added to the residue, and the resulting mixture was extracted with tert-butyl methyl ether. The combined organic extracts were washed with water and brine and dried (MgSO4). The title compound was obtained after removal of the solvent.

Quelle