Reaktion #168124

ord-6f00d4c4ad3c4b56a76c48960aff570a

Reaktionsgleichung

COc1ccc(-c2ccc(Cl)nn2)cc1OC
3-chloro-6-(3,4-dimethoxy-phenyl)-pyridazine
C1CCN2CCNC[C@H]2C1.Cl.Cl
(R)-octahydro-pyrido[1,2-a]-pyrazine, dihydrochloride
→
COc1ccc(-c2ccc(N3CCN4CCCC[C@@H]4C3)nn2)cc1OC.Cl.Cl
title compound
COc1ccc(-c2ccc(N3CCN4CCCC[C@@H]4C3)nn2)cc1OC.Cl.Cl
(R)-2-[6-(3,4-Dimethoxyphenyl)pyridazin-3-yl]octahydropyrido[1,2-a]pyrazine, dihydrochloride

Edukte

COc1ccc(-c2ccc(Cl)nn2)cc1OC
3-chloro-6-(3,4-dimethoxy-phenyl)-pyridazine
C1CCN2CCNC[C@H]2C1.Cl.Cl
(R)-octahydro-pyrido[1,2-a]-pyrazine, dihydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(3,4-dimethoxy-phenyl)-pyridazine and (R)-octahydro-pyrido[1,2-a]-pyrazine, dihydrochloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846677B2uspto-grants-2014_09